Bullistik FightLikeAFlynn

Our black & tan (tricolor) chocolate carrier son of Milkdud, Bullistik FightLikeAFLynn ‘Flynn’, has had the following health clearances through the Orthopedic Foundation for Animals and DNA Genetic lab GenSol:

CMR1 – Carrier/Not Affected
Canine Multifocal Retinopathy

Common Symptoms

Multifocal Retinopathy 1 is an inherited disorder of the Retina affecting several breeds of dog. Affected dogs typically present between 11 and 16 weeks of age with multiple discrete circular areas of retinal detachment with underlying fluid accumulation that are visible on an eye exam performed by a veterinarian. These blister-like lesions are typically found in both eyes and can appear gray, tan, orange or pink and vary in number, size and location. Progression of retinal changes is usually slow and new lesions are not noted after 6 to 12 months of age. Occasionally as affected dogs age, lesions appear to heal and are no longer visible on an eye exam. Generally the dog’s vision is not affected although vision loss has been described in some cases of multifocal retinopathy 1.

Breed-Specific Information for the French Bulldog

The Mutation of the BEST1 gene associated with multifocal retinopathy 1 has been identified in French Bulldogs in the Paw Print Genetics laboratory. Neither the frequency of the causal mutation nor its association with disease in this breed has been reported in the medical literature.

Dilated Cardiomyopathy
DM – Carrier/Not Affected

Common Symptoms

Degenerative Myelopathy is an inherited neurologic disorder caused by a Mutation of the SOD1 gene known to be carried by French bulldogs. This mutation is found in many breeds of dog, though it is not clear for French bulldogs whether all dogs carrying two copies of the mutation will develop the disease. The variable presentation between breeds suggests that there are environmental or other genetic factors responsible for modifying disease expression. The average age of onset for dogs with degenerative myelopathy is approximately nine years of age. The disease affects the White Matter tissue of the spinal cord and is considered the canine equivalent to amyotrophic lateral sclerosis (Lou Gehrig’s disease) found in humans. Affected dogs usually present in adulthood with gradual muscle Atrophy and loss of coordination typically beginning in the hind limbs due to degeneration of the nerves. The condition is not typically painful for the dog, but will progress until the dog is no longer able to walk. The gait of dogs affected with degenerative myelopathy can be difficult to distinguish from the gait of dogs with hip dysplasia, arthritis of other joints of the hind limbs, or intervertebral disc disease. Late in the progression of disease, dogs may lose fecal and urinary continence and the forelimbs may be affected. Affected dogs may fully lose the ability to walk 6 months to 2 years after the onset of symptoms. Affected small breed dogs, such as the French bulldog, often progress more slowly than affected large breed dogs and owners may postpone euthanasia until the dog is paraplegic.

Breed-Specific Information for the French Bulldog

The Mutation of the SOD1 gene associated with degenerative myelopathy has been identified in the French bulldog. The overall frequency of this disease in the breed and approximate age of disease onset are currently unreported for the French bulldog. However, in one study of 87 French bulldogs tested, 20.7% were carriers of the mutation and 5.7% were at-risk.

Hereditary Cataracts
Progressive Retinal Atrophy

Unfortunately, I have had to put the BULLISTIK® watermark on all of the health certifications for each of my Frenchies.  I was notified by PAWPRINT genetics that a man named Jason Trice, who apparently sells French Bulldogs, had stolen one of my health certifications from my website, altered it (poorly I might add) to scam his potential puppy buyer into believing the dam of his litter had been health screened.  Fortunately, the buyer thought the certificate looked fake and contacted PAWPRINT directly to verify.  PAWPRINT informed the puppy buyer that the certification results were factual but the certificate belonged to a French Bulldog owned by Bullistik French Bulldogs, not Jason Trice.  There are DISHONEST people selling French Bulldogs, so buyers beware and do your homework.

If you have any questions about Flynn’s health information, please contact me.